THE REASONS OF DISCONTINUATION OF TCU380A IUD AND COMPARE IT WITH THE NANO-CU IUD

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DOI: https://doi.org/10.29296/25419218-2018-03-10
Issue: 
3
Year: 
2018

Negin Mirzaee, A.I. Marakhova Peoples’ Friendship University of Russia, Institute of Biochemical Technologies and Nanotechnologies; Miklukho-Maklaya St., Build. 10/2, Moscow, 117198, Russian Federation

Introduction. The study was conducted to the reasons of discontinuation of TCu380A IUD and compare the antifertility effectiveness and side effects of the copper/low-density polyethylene nanocomposite IUD and the copper TCu380a IUD. Intrauterine devices are available in two types: 1 – copper, made of plastic and copper (TCu220c or TCu380a), releasing copper ions that have a spermicidal effect; 2 – hormonal type (Mirena), made of plastic, releasing levonorgestrel, synthetic progesterone. This study is devoted to a comparative study of two variants of copper intrauterine devices: TCu380a-IUD and Nano-Cu IUD. Materials and methods. Three hundred women who had a TCu380a inserted from June 2012 to June 2013 were selected for interviews in a 45 days period in 2017. The women were registered in the medical health centers of Sanandaj City, Iran. The criteria for entering the study were just the departure of the IUD during this time period. The increase in bleeding is the main reason for premature discontinuation of IUD (TCu380a) use. Results and conclusions. There were no statistically significant differences in the incidence of menstrual disorders (eg, dysmenorrhea, intermenstrual pelvic pain or intermenstrual bleeding) between two groups of patients with different types of IUD. According to the studies, TCu380a and TCu220c are almost identical in terms of undesirable reactions. In Nano-Cu IUD, the incidence of side effects was lower than in the Icu220c IUD, especially in the manifestation of severe menstrual bleeding. According to the results of and clinical trial, it is suggested that the new design of the Nano-Cu/LDPE IUDs may be a replacement for the conventional copper IUDs and deserves further study for clinical utilization and to solve the disadvantages of conventional IUDs.
Keywords: 
Contraception
Intrauterine Device
Cu/LDPE Nanocomposite
Vaginal Bleeding
Indomethacin
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