ANTIMICROBIAL ACTIVITY OF EXTRACTS FROM FRUITS OF TWO SPECIES OF IPECAC (FILIPENDULA)

Introduction. The problem of antibiotic resistance is not losing its relevance. In this connection, of interest are medicinal plants that have antimicrobial and anti-inflammatory activities, particularly the widespread meadowsweet (Filipendula ulmaria) and dropwort (Filipendula hexapetala), the herbaceous perennials of the Rose family (Rosaceae). Objective: to conduct a screening study of the antibacterial activity of extracts from meadowsweet and dropwort fruits. Material and methods. The investigation objects were aqueous and aqueous-alcohol extracts from meadowsweet and dropwort fruits. The minimum inhibitory concentration was determined by two-fold serial dilutions in the Mueller–Hinton broth. The gram-positive bacteria Bacillus cereus and Staphylococcus aureus, the gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa, and the yeast-like fungus Candida albicans were used as test cultures. Results. All the tested extracts exert an antibacterial effect. Meadowsweet fruit tincture (1:5) in 70% ethanol with the highest activity against Bacillus cereus strain had the widest spectrum of antibacterial activity. Conclusion. The findings indicate that it is feasible to use meadowsweet and dropwort fruits to prepare new antibacterial agents.