INVESTIGATION OF THE DIURETIC PROPERTIES OF A NEW SYNTHETIC SUBSTANCE

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DOI: https://doi.org/None
Issue: 
3
Year: 
2015

I.V. Smirnov (1,3), T.O. Murashko (1,3), N.L. Voloboi (1), A.A. Ivanov (2), A.O. Nemtsev (1,3), A.A. Bondarev (1,3), V.V. Udut (4) 1 -Altai State Medical University; 40, Lenin St., Barnaul 656308 2 -Tomsk National Research Polytechnic University; 30, Lenin St., Tomsk 634050 3 -Research Institute of Biological Medicine, Altai State Medical University; 61a, Lenin St., Barnaul 656049 4 -E.D. Goldberg Research Institute of Pharmacology, Siberian Branch, Russian Academy of Sciences; 3, Lenin St., Tomsk 634028

The paper gives the results of designing a safe synthetic diuretic agent whose advantages are a combination of synthetic and herbal diuretics. The new phenolglycoside compound 4-carboxyphenyl-o-D-glucopyranoside sodium salt was produced by organic synthesis via glycosylation catalyzed by boron trifluoride etherate. The structure of the resultant glycoside was identified by NMR spectroscopy. The animal experiments were carried out to investigate the diuretic properties of the new compound versus the known diuretics furosemide and arbutin. Its diuretic activity was assessed from the volume of excreted urine where the levels of sodium and potassium ions were measured. 4-carboxyphenylo-D-glucopyranoside sodium salt was found to have a mild diuretic effect unassociated with the urinary excretion of electrolytes.
Keywords: 
4-carboxyphenyl-o-D-glucopyranoside sodium salt
furosemide
arbutin
diuretic effect
urine volume
sodium and potassium ions
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