SEARCH FOR NOVEL R-BENZYLIDENE HYDRAZIDES OF NH-4-METHYLBENZOYL-5-IODOANTHRANILIC ACID WITH ANTI-INFLAMMATORY ACTIVITY

Introduction. N-substituted anthranilic acid derivatives are of interest due to a variety of their biological effects and low toxicity. Objective: to make computational prediction and subsequent experimental investigation of the biological activity of substituted NH-4-methylbenzoyl-5-iodoanthranilic acid hydrazides. Material and methods. Computational prediction of the biological activity of the novel compounds was carried out applying an online Pass program. The anti-inflammatory effect of the compounds was studied in a laboratory, by using a model of acute exudative inflammation during their oral administration in rats. Results. The computational prediction made showed that the test compounds might exhibit anti-inflammatory activity. Substances that promoted anti-inflammatory effects at the level of or slightly below those of the comparison drug were experimentally found. Conclusion. The compounds of the series of R-benzylidene hydrazides of NH-4-methylbenzoyl-5- iodoanthranilic acids have shown promise as biologically active compounds that exert an anti-inflammatory effect.