Determination of the wound-healing activity of a gel cream containing a synthetic selenoxanthene derivative

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DOI: https://doi.org/10.29296/25419218-2021-05-06
Issue: 
5
Year: 
2021

D.V. Zayats(3), O.V. Buyuklinskaya(1, 4), K.T. Erimbetov(2), O.V. Khoreva(1), N.S. Felenko(1) 1-North State Medical University, 51, Troitsky Prospect, Arkhangelsk 163000, Russian Federation; 2-Park of Active Molecules Research Center, 3, Kievskoe Shosse, Obninsk, Kaluga Region 249030, Russian Federation; 3-ZAO «PHARMA-SEVER», 4, Georgiy Sedov St., Severodvinsk 164501, Russian Federation; 4- Saint Petersburg Chemopharmaceutical University, 14A, Prof. Popov St., Saint Petersburg 197022, Russian Federation

Actuality: In this timethere are many different topical medicines inducing wound healing. Many drug forms or their active substances are produced abroad. Active substance selenopyrane with antioxidant, immunomodulatory and other actions was synthesized by research center “Park of activemolecules” (Obninsk). Topical action of substance has not been researched. Research purpose: study of wound healing activity of gel-cream, containing 1% selenopyraneon a model of a full-thickness planar wound in rats. Material and methods: wound healing activity of gel-cream, containing 1% selenopyrane has researched on model of a full-thickness planar wound in rats. Animals were divided into 3 groups: I – intact group; II – group of rats, were treated by gel-cream with selenopyrane; III – group of rats, were treated by dexpanthenol cream (comparison drug). Histological preparations of skin from wound area were made after the end of research (day 14). Results: On the 3rd day of experiment relative wound area in animal treated by selenopyrane was 2.1 % less than in intact rats but differences were not statistically significant. On the 5th day of experiment there was statistically significant difference of relative wound area in II group of animals in comparison with I (intact) group: 45.8% and 64.6% accordingly. Thus, gel-cream containing 1% selenopyran accelerated the onset of the wound process second phase– proliferation phase. Histological research showed that gel-cream containing of 1% selenopyran stimulates the epithelization of the wound defect of the skin with epidermis layers differentiation.
Keywords: 
selenopyrane
selenoxanthene
wound healing action
gel-cream
model of a full-thickness planar wound
rats
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