D.V. Dedov Tver State Medical University of the Ministry of Health of the Russian Federation, 4, Sovetskaya str., Tver, 170100, Russian Federation; Tver Regional Clinical Cardiology Dispensary, 19, Komsomolsky Avenue, Tver, 170041, Russian Federation

Introduction. Selenium is a trace element with pronounced catalytic properties. It is an important element for maintaining a healthy physiological state of the body. Selenium is involved in the regulation of immune system functions. Decreased selenium levels in patients with heart failure is associated with a deterioration of exercise tolerance, quality of life, and an unfavorable prognosis. Selenium deficiency causes irreversible damage in brain depletion. Selenium intake in physiological doses is crucial for human health and reproductive functions. Objective of the study. To study the literature data on Russian and foreign researches of significance of selenium and selenium-containing preparations for the organism and their role in prevention of various diseases. Material and methods. The review-analytical research of 6 Russian and 23 foreign articles was carried out. They were published in the period from 1994 till 2021. Results. It has been established that the biological activity of selenium is determined not only by the dose, but also by the chemical forms of the trace element. Its anticarcinogenic and cardioprotective effects essentially depend on them. It was found that Se exists in 2 forms: inorganic (selenite and selenite) and organic (selenomethionine and selenocysteine). The organic form of selenium, selenocysteine, is more bioavailable than other selenium derivatives. The above-ground part of the plant Astragalus woolly-flowered is a source of selenocysteine. It is used to manufacture SELENBIO for women vitamin-mineral complex. Important components of SELENBIO for women are also vitamins C, E and zinc. Conclusion. Components of SELENBIO for women are mutually complementary and reinforce each other's action. All together they provide a powerful total antioxidant effect, reliable protection of the female body from cardiovascular, hormonal, oncological diseases, pathology of the musculoskeletal system, while delaying the aging process, preserving the beauty and health of the skin, hair and nails.


  1. Polubojarinov P.A., Elistratov D.G., Shvets V.I. Metabolizm i mehanizm toksichnosti selensoderzhaschih preparatov, ispol'zuemyh dlja korrektsii defitsita mikroelementa selena. Tonkie himicheskie tehnologii. 2019; 14 (1): 5–24. [Poluboyarinov P.A., Elistratov D.G., Shvets V.I. Metabolism and mechanism of toxicity of selenium – containing supplements used for optimizing human selenium status. Fine Chemical Technologies. 2019; 14 (1): 5–24. (in Russian)]
  2. Huang X., Dong Y.L., Li T., Xiong W. et al. Dietary Selenium Regulates microRNAs in Metabolic Disease: Recent Progress. Nutrients. 2021;13(5):1527. DOI: 10.3390/nu13051527.
  3. Al-Mubarak A.A., van der Meer P., Bomer N. Selenium, Selenoproteins, and Heart Failure: Current Knowledge and Future Perspective. Curr Heart Fail Rep. 2021;18 (3): 122–31. DOI: 10.1007/s11897-021-00511-4.
  4. Ye R., Huang J., Wang Z., Chen Y., Dong Y. Trace Element Selenium Effectively Alleviates Intestinal Diseases. Int J Mol Sci. 2021; 22 (21): 11708. DOI: 10.3390/ijms222111708.
  5. Veisa V., Kalere I., Zake T., Strele I. et al. Assessment of Iodine and Selenium Nutritional Status in Women of Reproductive Age in Latvia. Medicina (Kaunas). 2021; 57 (11): 1211. DOI: 10.3390/medicina57111211.
  6. Lamarche J., Ronga L., Szpunar J., Lobinski R. Characterization and Quantification of Selenoprotein P: Challenges to Mass Spectrometry. Int J. Mol. Sci. 2021; 22 (12): 6283. DOI: 10.3390/ijms22126283.
  7. Rayman M.P. Selenium and human health. Lancet. 2012; 379 (9822): 1256–68. DOI: 10.1016/S0140-6736(11)61452-9.
  8. Fakhrolmobasheri M., Mazaheri-Tehrani S., Kieliszek M., Zeinalian M. et al. COVID-19 and Selenium Deficiency: a Systematic Review. Biol Trace Elem Res. 2021; 5: 1–12. DOI: 10.1007/s12011-021-02997-4.
  9. Kobayashi R., Hasegawa M., Kawaguchi C., Ishikawa N. et al. Thyroid function in patients with selenium deficiency exhibits high free T4 to T3 ratio. Clin Pediatr Endocrinol. 2021; 30 (1): 19–26. DOI: 10.1297/cpe.30.19.
  10. Rath A.A., Lam H.S., Schooling CM. Effects of selenium on coronary artery disease, type 2 diabetes and their risk factors: a Mendelian randomization study. Eur J. Clin. Nutr. 2021; 75 (11): 1668–78. DOI: 10.1038/s41430-021-00882-w.
  11. Tan Q.H., Huang Y.Q., Liu X.C., Liu L. et al. A U-Shaped Relationship Between Selenium Concentrations and All-Cause or Cardiovascular Mortality in Patients With Hypertension. Front Cardiovasc Med. 2021; 8: 671618. DOI: 10.3389/fcvm.2021.671618.
  12. Gać P., Poręba M., Januszewska L., Prokopowicz A. et al. The Total Antioxidant Status, Serum Selenium Concentrations and the Ultrasound Assessment Carotid Intima Media Thickness in Patients with Arterial Hypertension. Antioxidants (Basel). 2021; 10 (1): 63. DOI: 10.3390/antiox10010063.
  13. Zhang Z., Chang C., Zhang Y., Chai Z. et al. The association between serum selenium concentration and prognosis in patients with heart failure in a Chinese population. Sci Rep. 2021; 11 (1): 14533. DOI: 10.1038/s41598-021-93873-7.
  14. Mojadadi A., Au A., Salah W., Witting P. et al. Role for Selenium in Metabolic Homeostasis and Human Reproduction. Nutrients. 2021;13 (9): 3256. DOI: 0.3390/nu13093256.
  15. Kieliszek M., Bano I., Zare H. A Comprehensive Review on Selenium and Its Effects on Human Health and Distribution in Middle Eastern Countries. Biol Trace Elem Res. 2021. DOI: 10.1007/s12011-021-02716-z.
  16. Ibrahim SAZ., Kerkadi A., Agouni A. Selenium and Health: An Update on the Situation in the Middle East and North Africa. Nutrients. 2019; 11 (7): 1457. doi: 10.3390/nu11071457.
  17. Stoffaneller R., Morse N.L. A review of dietary selenium intake and selenium status in Europe and the Middle East. Nutrients. 2015; 7 (3): 1494–537. DOI: 10.3390/nu7031494.
  18. Fairweather-Tait S. J., Bao Y., Broadley M. R., Collings R. et al. Selenium in human health and disease. Antioxid. Redox Signal. 2011; 14 (7): 1337–83.
  19. Sunde R. A. Selenium. Present Knowledge in Nutrition : 9th ed./eds. Bowman B., Russell R. Washington, DC: International Life Sciences Institute. 2006; 480–97.
  20. Polubojarinov P.A., Golubkina N.A., Glebova N.N. Perspektivnost' ispol'zovanija selenotsistina dlja poluchenija obogaschennyh selenom mjasa i jaits perepela japonskogo (Coturnix coturnix japonica). Vestnik Orenburgskogo gosudarstvennogo universiteta. 2016; 10 (198): 74–8. [Poluboyarinov P.A., Golubkina N.A., Glebova N.N. Prospects of using selenocystin for selenium-enriched meat and eggs of Japanese quail (Coturnix coturnix japonica). Bulletin of the Orenburg State University. 2016; 10 (198): 74–8. (in Russian)]
  21. Golubkina N.A., Polubojarinov P.A., Sindireva A.V. Selen v produktah rastitel'nogo proishozhdenija. Voprosy pitanija. 2017; 86 (2): 63–9. [Golubkina N.A., Poluboyarinov PA, Sindireva AV. Selenium in the products of plant origin. Nutrition issues. 2017; 86 (2): 63–9 (in Russian)]
  22. He M.-J., Zhang S.-Q., Liu L., Han F. Breast milk selenocystine as a biomarker for selenium intake in lactating women at differential geographical deficiency risk in China. Asia Pacific J. of Clinical Nutrition. 2019; 28 (2): 341–6.
  23. Kohan S.T., Krivosheeva E.M. Eksperimental'noe issledovanie antioksidantnyh svojstv rastitel'nyh adaptogenov. Vestnik farmatsii. 2010; 4 (50): 29–33. [Kokhan S.T., Krivosheeva E.M. Experimental study of antioxidant properties of plant adaptogens. Bulletin of Pharmacy. 2010; 4 (50): 29–33 (in Russian)]
  24. Polubojarinov P.A. Biofortifikatsija rastenij astragala Astragala sherstistotsvetkovogo (Astragalus dasyanthus Pall.) aminokislotoj L-selenotsisteinom. [Poluboyarinov P.A. Biofortification of Astragalus astragalus woolly-flowered (Astragalus dasyanthus Pall.) plants with the amino acid L-selenocysteine. (in Russian)] URL: (data obraschenija 13.12.2021).
  25. Brigelius-Flohe R., Traber M.G. Vitamin E: function and metabolism. FASEB J. 1999; 13 (10): 1145–55.
  26. Shahidi F., De Camargo A.C. Tocopherols and tocotrienols in common and emerging dietary sources: Occurrence, applications, and health benefits. Int. J. Mol. Sci. 2016; 17 (10): 1745.
  27. Borisov V.V. Mikroelementy selen i tsink v organizme zhenschiny i muzhchiny: problemy i reshenija. Consilium Medicum. 2018; 20 (7): 63–8. [Borisov V.V. Micronutrients selenium and zinc in women and men: problems and solutions. Consilium Medicum. 2018; 20 (7): 63–8 (in Russian)]
  28. Padayatty S.J., Katz A., Wang Y., Eck P., Kwon O., Lee J.-H., Chen S., Corpe C., Dutta A., Dutta S. K., Levine M. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J. Am. Coll. Nutr. 2003; 22 (1): 18–35.
  29. Bedwal R., Bahuguna A. Zinc, copper and selenium in reproduction. Experientia. 1994; 50 (7): 626–40.