Macro- and microscopic analysis of the herbal sedative composition

DOI: https://doi.org/10.29296/25419218-2022-05-03
Issue: 
5
Year: 
2022

Y.E. Prozhogina(2), M.A. Javakhyan(1, 2), N.V. Bobkova(1, 3)
1-Lomonosov Moscow State University (Lomonosov Moscow State University), Faculty of Fundamental Medicine, 27 Lomonosovsky Ave., bldg. 1, Moscow, 119192, Russian Federation;
2-All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (FGBNU VILAR), 7, Greena str., Moscow, 117216, Russian Federation;
3-Sechenov First Moscow State Medical University (Sechenov University), 8/2, Trubetskaya str., Mosсow, 119991, Russian Federation

Introduction. Solving the problems of psychoemotional health is one of the priorities of modern medicine. An increase in the level of stress and anxiety can be expressed not only in a worsening of psychological well-being, but also in the development of somatic diseases. Sedative medicines are one of the most effective and promising areas of pharmacotherapy. Objective: to conduct a pharmacognostic analysis of the self-developed sedative medicinal herbs composition to establish the authenticity of the components included to ensure the possibility of introducing the medicine into pharmaceutical practice. Material and methods. The object of the study is a four-component sedative herbal composition consisting of the herb of motherwort cordial (common motherwort) (Leonurus cardiaca L.), herb of St. John's wort (Hypericum perforatum L.), herb of lemon balm (Melissa officinalis L.) and herb of thyme (Thymus serpyllum L.). Methods – techniques of macro- and microscopic analysis. Results. The characteristics of the authenticity of the herbal sedative composition, including a description of external signs and microscopic analysis, are determined. Conclusion. The analysis was carried out which is necessary stage for the possibility of introduction of the medicine into pharmaceutical practice.

Keywords: 
herbal medicines
sedative effect
herbs compositions
motherwort
St. john's wort
lemon balm
thyme.

References: 
  1. The State Pharmacopoeia оf The Russian Federation, XIV-ed. [Electronic resource]. Access mode: https://femb.ru/record/pharmacopea14 (in Russian)
  2. Aliev M.A. Problems of epidemiologic research work and prevalence of psychic disorders in modern world. Vestnik nevrologii, psihiatrii i nejrohirurgii. 2017; 8: 9–16. (in Russian)
  3. Shalnova S.A., Evstifeeva S.E., Deev A.D., Artamonova G.V. et al. The prevalence of anxiety and depression in different regions of the Russian Federation and its association with sociodemographic factors (according to the data of the ESSE-RF study). Terapevticheskij arhiv. 2014; 6 (12): 53–60. DOI: 10.17116/terarkh2014861253-60 (in Russian)
  4. Mitihina I.A., Mitihin V.G., Yastrebov V.S., Limankin O.V. Epidemiological models of the influence of socio-economic factors on the mental health indicators of the population of the Russian Federation in the period 1992–2008. Zhurnal nevrologii i psihiatrii im. S.S. Korsakova. 2012; 4: 4−10 (in Russian)
  5. Burtscher J., Burtscher M., Millet G.P. (Indoor) isolation, stress, and physical inactivity: Vicious circles accelerated by COVID-19? Scand J. Med. Sci Sports. 2020; 30 (8): 1544–5. DOI: 10.1111/sms.13706
  6. Shah S.M.A., Mohammad D., Qureshi M.F.H., Abbas M.Z., Aleem S. Prevalence, psychological responses and associated correlates of depression, anxiety and stress in a global population, during the coronavirus disease (COVID-19) pandemic. Community Ment Health J. 2021; 57 (1): 101–10. DOI: 10.1007/s10597-020-00728-y
  7. Tokareva M.G., Prozhogina Y.E., Kalenikova E.I., Dzhavakhyan M.A. The analysis of modern Russian market of sedative herbal medicines. Voprosy obespechenija kachestva lekarstvennyh sredstv. 2019; 24 (2): 4–19 (in Russian)
  8. Medicines in Russia: The VIDAL Guideline, 27-ed. Moscow: Vidal Rus., 2021; 1120 (in Russian)
  9. Unified structured directory – catalog of medicines for medical use of the Ministry of Health of the Russian Federation [Electronic resource]. Access mode: https://esklp.egisz.rosminzdrav.ru (accessed: 20.11.2021) (in Russian)
  10. State Register of Medicines of the Ministry of Health of the Russian Federation [Electronic resource]. Access mode: https://grls.rosminzdrav.ru (accessed: 20.11.2021) (in Russian)
  11. List of vital and essential medicines for Medical Use for 2021: Decree of the Government of the Russian Federation dated 12.10.2019 No.2406-r "On approval of the List of vital and essential medicines for 2020" with amendments made by Decree of the Government of the Russian Federation dated November 23, 2020 No.3073-r, effective from January 1, 2021 (in Russian)
  12. Bekker R.A., Bykov Yu.V. Spicy and aromatic plants in psychiatry and neurology: a scientific review. Part I. Siberian J. of Life Sciences and Agriculture. 2018; 10 (1): 90–123. DOI: 10.12731/wsd-2018-1-90-123 (in Russian)
  13. Tokareva M.G., Prozhogina Y.E., Kalenikova E.I., Dzhavakhyan M.A. The pharmacognostic and pharmacological aspects of the creating of the new sedative drugs based on medicinal plant raw materials. Voprosy biologicheskoj, medicinskoj i farmacevticheskoj himii. 2018; 21 (3): 3−11. DOI: 10.29296/25877313-2018-03-01 (in Russian)
  14. Martynov A.M., Dargaeva T.D. Micromorphological elements of the "BRONKHOLISAN" herbal medicinal mixture. Mezhdunarodnyj nauchno-issledovatel'skij zhurnal. 2021; 1–3 (103): 73–8. DOI 10.23670/IRJ.2021.103.1.067 (in Russian)
  15. Mardaryeva K.R., Ovsyannikova T.P. Macroscopic and microscopic analysis of the «Stop-urate» plant composition. Collection of scientific articles of the All-Russian Scientific and practical Conference of students and young scientists with international participation, Irkutsk, 3–4 December. 2020; 97–103 (in Russian)
  16. Samylina I.A., Ermakova V.A., Bobkova N.V., Anosova O.G. Pharmacognosy. Atlas. Volume 3. Moscow: GEOTAR-Media, 2009; 488 (in Russian)