СОВРЕМЕННЫЕ ОСНОВООБРАЗУЮЩИЕ ВЕЩЕСТВА В ТЕХНОЛОГИИ МЯГКИХ ЛЕКАРСТВЕННЫХ ФОРМ

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DOI: https://doi.org/None
Номер журнала: 
8
Год издания: 
2015

М.А. Джавахян*, канд. фарм. наук, С.П. Комкова, А.В. Давыдова Всероссийский научно-исследовательский институт лекарственных и ароматических растений; 117216, Москва, ул. Грина, 7, стр. 1 Е-mail: akopovamarina13@mail.ru

Обзор посвящен современным основам для мягких лекарственных форм, а именно кремов для лечения инфекционных заболеваний кожи. С точки зрения биомедицинской фармации рациональный выбор основы с учетом нозологии заболевания, а также ее стадии во многом определяет фармакологическую активность лекарственной формы. Рассматриваются преимущества применения современных основ для мягких лекарственных форм – кремов.
Ключевые слова: 
мягкая лекарственная форма
вспомогательное вещество
крем
Для цитирования: 
Джавахян М.А., Комкова С.П., Давыдова А.В. СОВРЕМЕННЫЕ ОСНОВООБРАЗУЮЩИЕ ВЕЩЕСТВА В ТЕХНОЛОГИИ МЯГКИХ ЛЕКАРСТВЕННЫХ ФОРМ . Фармация, 2015; 64 (8): 43-47
Список литературы: 
  1. Охотникова В.Ф, Левчук Т.А.,Гагулашвили Л.И., Джавахян М.А., Семкина О.А. Впомогательные вещества, используемые в технологии мягких лекарственных форм (мазей, гелей, линиментов, кремов). Химико-фармацевтический журнал 2005; 9; 45–48. [Okhotnikova V.F, Levchuk T.A.,Gagulashvili L.I., Dzhavahyan M.A., Semkina O.A. Drug vehicles used in technology of soft medicinal forms (ointments, gels, linments, creams). Himiko-farmacevticheskij zhurnal 2005; 9; 45–48 (in Russian)].
  2. Klein К. Formulating water-in-oil emulsions: a scary endeavor. Cosmetics & Toiletries, 2003; 118: 24–25.
  3. Savić S.1., Weber C., Savić M.M., Müller-Goymann C. Natural surfactant-based topical vehicles for two model drugs: Influence of different lipophilic excipients on in vitro/in vivo skin performance. Int J Pharm. 2009, Nov 3; 381 (2): 220–230.
  4. Barel A.O., Paye M., Maibach.H.I., eds. Handbook of Cosmetic Science and Technology. Photochem Photobiol Sci, 2006; 5: 169–177.
  5. Annual Review of Cosmetic Ingredient Safety Assessments: 2005/2006/ International journal of Toxicology, 27 (Suppl.1): 77–142.
  6. Annual Review of Cosmetic Ingredient Safety Assessments: 2004/2005/ International journal of Toxicology, 27 (Suppl.1): 77–142.
  7. Zsóka Weiszhár, Judit Czúcz, Csaba Révész, László Rosivall, János Szebeni, Zoltán Rozsnyay Complement activation by polyethoxylated pharmaceutical surfactants: Cremophor-EL, Tween-80 and Tween-20. European Journal of Pharmaceutical Sciences, 45 (2012): 492–498.
  8. Simoesa S.I., Tapadasa J.M., Marquesa C.M., Cruza M.E.M., Martinsa M.B.F., Cevcb G. Permeabilisation and solubilisation of soybean phosphatidylcholine bilayer vesicles, as membrane models, by polysorbate, Tween 80 European Journal of Pharmaceutical Sciences, 26 (2005): 307–317.
  9. Yuan, Yuan et al. Characterization and stability evaluation of β-carotene nanoemulsions prepared by high pressure homogenization under various emulsifying conditions. Food Research International, 41.1 (2008): 61–68.
  10. Singh, Vinay K. et al. Development and Characterization of Sorbitan Monostearate and Sesame Oil-Based Organogels for Topical Delivery of Antimicrobials. AAPS Pharm. Sci. Tech. (2014): 1–13.
  11. Zhao, Qiangzhong et al. Effect of sorbitan monostearate on the physical characteristics and whipping properties of whipped cream. Food chemistry, 141.3 (2013): 1834–1840.
  12. Vucinić-Milanković N.1., Savić S., Vuleta G., Vucinić S. The Physicochemical Characterization and in vitro/in vivo evaluation of natural-sulfactants-based emulsion as vehicles for diclofenac diethylamin. Drug Dev Ind Pharm., 2007; Mar; 33 (3): 221–234.
  13. Baudonnet L., Grossiord J.L., Rodriguez F. Physicochemical Characterization and in vitro release of salicylic acid from O/W emulsions prepared with Montanov 68: effect of formulation parameters. Drug Dev. Ind. Pharm., 2004; 30 (9): 975–984.
  14. Kiran Kumar M., Manish H. Shah, Anant Ketkar, Mahadik K.R. Anant Paradkar. Effect of drug solubility and different excipients on floating behaviour and release from glyceryl monooleate matrices Int. J. Pharm., 2004; Mar 19; 272 (1-2): 151–160.
  15. Kumar R., Kumar M.S. Multiple Emulsions: A Review. International Journal of Recent Advances in Pharmaceutical Research January, 2012; 2 (1): 9–19.
  16. Wang W.1., Zhang M.J1., Chu L.Y2. Microfluidic approach for encapsulation via double emulsions. Curr. Opin. Pharmacol., 2014; Sep 4;18: 35–41.
  17. J Jiao D.J. Burgess Rheology and stability of water-in-oil-in-water multiple emulsions containing Span 83 and Tween 80. AAPS Pharm. Sci. 2003; 5 (1): 7.
  18. Lautenschläger Н. Fats and oils in cosmetics – Mother Nature versus petrochemicals? (long version) Kosmetische Medizin, 2008 (2): 76–80.
  19. Аравийская Е.Р., Соколовский Е.В., Бахтина С.М., Пчелинцев М.В. Роль основы в глюкокортикостероидных препаратах: оптимальный состав и механизм действия. Vestn. Dermatol. Venerol. 2010; 2; 64–70. [Aravijskaya E.R., Sokolovskij E.V., Bahtina S.M., Pchelincev M.V. The role of foundations in glucocorticosteroid preparations: the optimal composition and mechanism of action. Vestn. Dermatol. Venerol. 2010; 2; 64–70 (in Russian)].
  20. Expert Panel members are: Chairman, Wilma F. Bergfeld, M.D., F.A.C.P.; Donald V. Belsito, M.D.; Curtis D. Klaassen, Ph.D.; James G. Marks, Jr., M.D.; Ronald C. Shank, Ph.D.; Thomas J. Slaga, Ph.D.; and Paul W. Snyder, D.V.M., Ph.D. The CIR Director is F. Alan Andersen, Ph.D. Final Report of the Cosmetic Ingredient Review September 23, 2008
  21. Rawlings A.V1., Lombard K.J. A review on the extensive skin benefits of mineral oil. Int. J. Cosmet. Sci., 2012; Dec; 34 (6): 511–518.
  22. Al-Adham I.S.1., Ashour H., Al-Kaissi E., Khalil E., Kierans M., Collier P.J. Studies on the kinetics of killing and the proposed mechanism of action of microemulsions against fungi Int. J. Pharm., 2013 Sep 15; 454 (1): 226–232.
  23. Fruijtier-Pölloth C. Safety assessment on polyethylene glycols (PEGs) and their derivatives as used in cosmetic products. Toxicology, 2005; 214 (1): 1–38.
  24. Lowther A., Thomas McCormick, and S. Nedorost. Systemic contact dermatitis from propylene glycol. Dermatitis, 2008; 19 (2): 105–108.
  25. Lessmann H., Schnuch A., Geier J., Uter W. Skin-sensitizing and irritant properties of propylene glycol. Contact dermatitis, 2005; 53 (5): 247–259.
  26. Mustoe Th. A. Evolution of silicone therapy and mechanism of action in scar management. Aesthetic plastic surgery, 2008; 32.1: 82–92.